macrophage migration inhibitory factor (MIF)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:cytokine gptkb:protein
gptkbp:alternativeName	gptkb:GIF glycosylation-inhibiting factor
gptkbp:associatedWith	gptkb:inflammatory_bowel_disease gptkb:Alzheimer's_disease gptkb:systemic_lupus_erythematosus asthma malaria rheumatoid arthritis
gptkbp:discoveredBy	gptkb:John_David
gptkbp:discoveredIn	1966
gptkbp:encodedBy	gptkb:MIF_gene
gptkbp:Entrez_Gene_ID	4282
gptkbp:enzyme	tautomerase activity
gptkbp:expressedIn	gptkb:pituitary_gland gptkb:T_cells macrophages
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	regulation of immune response inhibition of macrophage migration pro-inflammatory mediator
gptkbp:GO	gptkb:GO:0005125
gptkbp:HGNC_ID	7097
gptkbp:inhibitedBy	4-IPP ISO-1
gptkbp:involvedIn	gptkb:cancer sepsis autoimmune diseases
gptkbp:locatedOnChromosome	22q11.23
gptkbp:molecularWeight	12.5 kDa
gptkbp:OMIM	153620
gptkbp:orthologIn	mouse Mif rat Mif
gptkbp:PDB	1MFI
gptkbp:postTranslationalModification	phosphorylation oxidation
gptkbp:recipient	gptkb:CD74 gptkb:CXCR2 gptkb:CXCR4
gptkbp:regulates	apoptosis cell proliferation glucocorticoid action
gptkbp:structure	homotrimer
gptkbp:UniProtID	P14174
gptkbp:bfsParent	gptkb:CD74
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	macrophage migration inhibitory factor (MIF)