macrophage migration inhibitory factor (MIF)

URI: https://gptkb.org/entity/macrophage_migration_inhibitory_factor_(MIF)
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
cytokine
gptkbp:alternativeName gptkb:GIF
glycosylation-inhibiting factor
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:systemic_lupus_erythematosus
asthma
malaria
rheumatoid arthritis
inflammatory bowel disease
gptkbp:discoveredBy gptkb:John_David
gptkbp:discoveredIn 1966
gptkbp:encodedBy gptkb:MIF_gene
gptkbp:Entrez_Gene_ID 4282
gptkbp:enzyme tautomerase activity
gptkbp:expressedIn gptkb:pituitary_gland
gptkb:T_cells
macrophages
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function regulation of immune response
inhibition of macrophage migration
pro-inflammatory mediator
gptkbp:GO gptkb:GO:0005125
gptkbp:HGNC_ID 7097
https://www.w3.org/2000/01/rdf-schema#label macrophage migration inhibitory factor (MIF)
gptkbp:inhibitedBy 4-IPP
ISO-1
gptkbp:involvedIn gptkb:cancer
sepsis
autoimmune diseases
gptkbp:locatedOnChromosome 22q11.23
gptkbp:molecularWeight 12.5 kDa
gptkbp:OMIM 153620
gptkbp:orthologIn mouse Mif
rat Mif
gptkbp:PDB 1MFI
gptkbp:postTranslationalModification phosphorylation
oxidation
gptkbp:recipient gptkb:CD74
gptkb:CXCR2
gptkb:CXCR4
gptkbp:regulates apoptosis
cell proliferation
glucocorticoid action
gptkbp:structure homotrimer
gptkbp:UniProtID P14174
gptkbp:bfsParent gptkb:CD74
gptkbp:bfsLayer 8