Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
gptkb:angiotensin-converting_enzyme
|
| gptkbp:cofactor |
zinc
|
| gptkbp:discoveredBy |
gptkb:Leonard_T._Skeggs,_Jr.
|
| gptkbp:EC_number |
3.4.15.1
|
| gptkbp:function |
inactivates bradykinin
converts angiotensin I to angiotensin II |
| gptkbp:gene |
gptkb:ACE
|
| https://www.w3.org/2000/01/rdf-schema#label |
kininase II
|
| gptkbp:inhibitedBy |
gptkb:enalapril
gptkb:captopril gptkb:lisinopril |
| gptkbp:location |
gptkb:cell_membrane
gptkb:kidney gptkb:testis lung endothelial cells |
| gptkbp:molecularWeight |
~150 kDa
|
| gptkbp:product |
gptkb:angiotensin_II
inactive bradykinin fragments |
| gptkbp:role |
gptkb:renin-angiotensin_system
regulation of blood pressure |
| gptkbp:significance |
target of ACE inhibitors for hypertension
|
| gptkbp:structure |
type I membrane protein
|
| gptkbp:substrate |
gptkb:angiotensin_I
gptkb:bradykinin |
| gptkbp:bfsParent |
gptkb:Angiotensin-converting_enzyme
|
| gptkbp:bfsLayer |
6
|