|
gptkbp:instanceOf
|
gptkb:drug
ACE inhibitor
|
|
gptkbp:approvalYear
|
1981
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
C09AA01
|
|
gptkbp:bioavailability
|
60-75%
|
|
gptkbp:brand
|
Capoten
|
|
gptkbp:CASNumber
|
62571-86-2
|
|
gptkbp:chemicalFormula
|
C9H15NO3S
|
|
gptkbp:contraindication
|
pregnancy
bilateral renal artery stenosis
history of angioedema
|
|
gptkbp:developedBy
|
gptkb:Squibb
|
|
gptkbp:discoveredBy
|
David Cushman
Miguel Ondetti
|
|
gptkbp:discoveredIn
|
gptkb:United_States
|
|
gptkbp:drugClass
|
antihypertensive
cardiovascular agent
|
|
gptkbp:eliminationHalfLife
|
2 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:firstSynthesized
|
1975
|
|
gptkbp:has_stereochemistry
|
S-enantiomer
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
captopril
|
|
gptkbp:KEGGID
|
gptkb:D00224
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits angiotensin-converting enzyme
|
|
gptkbp:MeSH_ID
|
D002198
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
217.29 g/mol
|
|
gptkbp:pregnancyCategory
|
gptkb:C_(Australia)
D (US)
|
|
gptkbp:proteinBinding
|
25-30%
|
|
gptkbp:PubChem_CID
|
44093
CHEMBL172
DB01197
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
cough
rash
hypotension
hyperkalemia
angioedema
|
|
gptkbp:solubility
|
freely soluble
|
|
gptkbp:UNII
|
96XD4U06UB
|
|
gptkbp:usedFor
|
heart failure
hypertension
diabetic nephropathy
post-myocardial infarction
|
|
gptkbp:bfsParent
|
gptkb:Donald_L._Gold
gptkb:EC_3.4.15.1
gptkb:kininase_II
|
|
gptkbp:bfsLayer
|
7
|