gptkbp:instanceOf
|
gptkb:drug
ACE inhibitor
|
gptkbp:approvedBy
|
gptkb:FDA
1985
|
gptkbp:ATCCode
|
C09AA02
|
gptkbp:bioavailability
|
60%
|
gptkbp:brand
|
gptkb:Epaned
gptkb:Renitec
gptkb:Vasotec
|
gptkbp:CASNumber
|
75847-73-3
|
gptkbp:category
|
prodrug
antihypertensive
|
gptkbp:chemicalFormula
|
C20H28N2O5
|
gptkbp:contraindication
|
pregnancy
history of angioedema
|
gptkbp:developedBy
|
gptkb:teprotide
|
gptkbp:discoveredBy
|
gptkb:Merck_&_Co.
|
gptkbp:discoveredIn
|
1980
|
gptkbp:eliminationHalfLife
|
11 hours
|
gptkbp:excretion
|
renal
|
gptkbp:genericAvailable
|
yes
|
https://www.w3.org/2000/01/rdf-schema#label
|
enalapril
|
gptkbp:interactsWith
|
gptkb:NSAIDs
lithium
diuretics
potassium-sparing diuretics
|
gptkbp:IUPACName
|
(S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline
|
gptkbp:KEGGID
|
gptkb:D07917
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
inhibits angiotensin-converting enzyme
|
gptkbp:MedlinePlusID
|
a686022
|
gptkbp:metabolism
|
gptkb:enalaprilat
|
gptkbp:molecularWeight
|
376.45 g/mol
|
gptkbp:pregnancyCategory
|
D (US)
|
gptkbp:proteinBinding
|
50-60%
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL137
5388968
DB00584
|
gptkbp:routeOfAdministration
|
oral
|
gptkbp:sideEffect
|
cough
hypotension
hyperkalemia
angioedema
|
gptkbp:UNII
|
R7T0YL8U1C
|
gptkbp:usedFor
|
heart failure
hypertension
left ventricular dysfunction
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
gptkbp:bfsParent
|
gptkb:Vasotec
|
gptkbp:bfsLayer
|
5
|