|
gptkbp:instanceOf
|
gptkb:drug
ACE inhibitor
|
|
gptkbp:approvalYear
|
1987
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
C09AA03
|
|
gptkbp:bioavailability
|
25%
|
|
gptkbp:brand
|
Prinivil
Zestril
|
|
gptkbp:CASNumber
|
83915-83-7
|
|
gptkbp:chemicalFormula
|
C21H31N3O5
|
|
gptkbp:contraindication
|
pregnancy
bilateral renal artery stenosis
history of angioedema
|
|
gptkbp:discoveredBy
|
gptkb:Merck_&_Co.
|
|
gptkbp:drugClass
|
ACE inhibitor
antihypertensive
|
|
gptkbp:eliminationHalfLife
|
12 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:firstSynthesized
|
1980
|
|
gptkbp:genericAvailable
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
lisinopril
|
|
gptkbp:interactsWith
|
gptkb:NSAIDs
gptkb:aliskiren
lithium
diuretics
potassium-sparing diuretics
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits angiotensin-converting enzyme
|
|
gptkbp:metabolism
|
not metabolized
|
|
gptkbp:molecularWeight
|
405.5 g/mol
|
|
gptkbp:onWHOListOfEssentialMedicines
|
yes
|
|
gptkbp:patentExpired
|
yes
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:riskFactor
|
renal dysfunction
hyperkalemia
angioedema
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
dizziness
cough
hypotension
renal impairment
hyperkalemia
|
|
gptkbp:usedFor
|
heart failure
hypertension
diabetic nephropathy
post-myocardial infarction
|
|
gptkbp:bfsParent
|
gptkb:EC_3.4.15.1
gptkb:kininase_II
gptkb:hydrochlorothiazide
|
|
gptkbp:bfsLayer
|
7
|