interleukin-4 receptor alpha

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein cell surface receptor
gptkbp:alternativeName	CD124 IL-4R alpha IL4RA
gptkbp:associatedWith	gptkb:atopic_dermatitis immunodeficiency allergic asthma
gptkbp:binds	gptkb:interleukin-4 gptkb:interleukin-13
gptkbp:discoveredBy	1989
gptkbp:expressedIn	gptkb:B_cells gptkb:T_cells gptkb:basophils gptkb:mast_cells endothelial cells fibroblasts monocytes
gptkbp:formsComplexWith	gptkb:common_gamma_chain interleukin-13 receptor alpha 1
gptkbp:function	mediates immune response involved in Th2 cell differentiation regulates IgE production
gptkbp:gene	IL4R
gptkbp:HGNC_ID	6015
https://www.w3.org/2000/01/rdf-schema#label	interleukin-4 receptor alpha
gptkbp:locatedOnChromosome	gptkb:16p12.1 16
gptkbp:molecularWeight	approximately 140 kDa
gptkbp:OMIM	147781
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:signal_transduction_pathway	gptkb:JAK-STAT_pathway
gptkbp:species	gptkb:Homo_sapiens
gptkbp:structure	type I transmembrane protein
gptkbp:targetOfDrug	gptkb:dupilumab
gptkbp:UniProtID	gptkb:P24394
gptkbp:bfsParent	gptkb:dupilumab gptkb:Dupixent_(dupilumab) gptkb:Dupilumab gptkb:pitrakinra
gptkbp:bfsLayer	7