Statements (57)
Predicate | Object |
---|---|
gptkbp:instance_of |
gptkb:monoclonal_antibody
|
gptkbp:administered_by |
subcutaneous injection
|
gptkbp:approves |
gptkb:2017
gptkb:FDA |
gptkbp:availability |
prescription only
|
gptkbp:chemical_formula |
C30 H32 N6 O7 S
|
gptkbp:clinical_trial |
Phase 3
|
gptkbp:clinical_use |
long-term management
|
gptkbp:contraindication |
hypersensitivity to dupilumab
|
gptkbp:developed_by |
gptkb:Sanofi
gptkb:Regeneron_Pharmaceuticals |
gptkbp:financial_stability |
stable until expiration date
|
gptkbp:formulation |
solution for injection
|
https://www.w3.org/2000/01/rdf-schema#label |
Dupilumab
|
gptkbp:indication |
chronic rhinosinusitis with nasal polyps
moderate to severe atopic dermatitis eosinophilic esophagitis moderate to severe asthma |
gptkbp:interacts_with |
no significant drug interactions
|
gptkbp:invention |
patented
|
gptkbp:is_monitored_by |
monitor for allergic reactions
monitor for eosinophilia monitor for ocular symptoms |
gptkbp:marketed_as |
gptkb:Dupixent
|
gptkbp:mechanism_of_action |
inhibits IL-4 and IL-13 signaling
|
gptkbp:packaging |
auto-injector
pre-filled syringe |
gptkbp:patient_education |
importance of adherence to therapy
advise on potential side effects instruct on injection technique |
gptkbp:patient_population |
adults
children over 6 years old |
gptkbp:pharmacokinetics |
half-life of approximately 26 days
|
gptkbp:price |
high cost
|
gptkbp:provides_guidance_on |
included in treatment guidelines
|
gptkbp:research_focus |
autoimmune diseases
allergic diseases chronic inflammatory diseases |
gptkbp:route_of_administration |
subcutaneous
|
gptkbp:safety_features |
generally well tolerated
|
gptkbp:service_frequency |
every 2 weeks
initial loading dose |
gptkbp:side_effect |
headache
urticaria injection site reactions conjunctivitis pharyngitis |
gptkbp:storage |
refrigerated at 2-8° C
|
gptkbp:targets |
gptkb:IL-13_receptor
gptkb:IL-4_receptor |
gptkbp:used_for |
gptkb:asthma
atopic dermatitis chronic rhinosinusitis with nasal polyps |
gptkbp:weight |
600.7 g/mol
|
gptkbp:bfsParent |
gptkb:EMD_Serono
gptkb:Dupixent |
gptkbp:bfsLayer |
5
|