|
gptkbp:instanceOf
|
gptkb:protein
cell surface receptor
|
|
gptkbp:alternativeName
|
CD25 (for alpha subunit)
IL-2R
Tac antigen
|
|
gptkbp:associatedWith
|
leukemia
autoimmune diseases
|
|
gptkbp:binds
|
gptkb:interleukin-2
|
|
gptkbp:chromosome_location_(IL2RA)
|
10p15
|
|
gptkbp:chromosome_location_(IL2RB)
|
22q13
|
|
gptkbp:chromosome_location_(IL2RG)
|
Xq13
|
|
gptkbp:component
|
cytokine receptor family
|
|
gptkbp:discoveredBy
|
1981
|
|
gptkbp:expressedIn
|
gptkb:natural_killer_cells
gptkb:T_cells
gptkb:regulatory_T_cells
activated B cells
|
|
gptkbp:foundIn
|
immune system
|
|
gptkbp:function
|
regulates immune response
mediates interleukin-2 signaling
|
|
gptkbp:gene_encoding_subunit
|
gptkb:IL2RG_gene
gptkb:IL2RA_gene
IL2RB gene
|
|
gptkbp:has_high_affinity_form
|
trimeric (alpha, beta, gamma)
|
|
gptkbp:has_intermediate_affinity_form
|
beta and gamma subunits
|
|
gptkbp:has_low_affinity_form
|
alpha subunit only
|
|
gptkbp:has_soluble_form
|
soluble IL-2 receptor (sIL-2R)
|
|
gptkbp:HGNC_ID_(IL2RA)
|
6008
|
|
gptkbp:HGNC_ID_(IL2RB)
|
6009
|
|
gptkbp:HGNC_ID_(IL2RG)
|
6010
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interleukin-2 receptor
|
|
gptkbp:involves
|
T cell proliferation
immune tolerance
lymphocyte activation
|
|
gptkbp:MeSH_ID
|
D016232
|
|
gptkbp:OMIM
|
147730
|
|
gptkbp:structure
|
heterotrimeric
|
|
gptkbp:subunit
|
gptkb:IL2RG
gptkb:IL2RB
IL2RA
|
|
gptkbp:targetOfDrug
|
gptkb:basiliximab
gptkb:daclizumab
|
|
gptkbp:UniProt_ID_(alpha)
|
P01589
|
|
gptkbp:UniProt_ID_(beta)
|
P14784
|
|
gptkbp:UniProt_ID_(gamma)
|
P31785
|
|
gptkbp:used_as_biomarker
|
gptkb:graft-versus-host_disease
leukemia
immune activation
|
|
gptkbp:bfsParent
|
gptkb:CD25
|
|
gptkbp:bfsLayer
|
6
|