insulin-like growth factor I protein

URI: https://gptkb.org/entity/insulin-like_growth_factor_I_protein
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:IGF-1
gptkbp:associatedWith gptkb:cancer
gptkb:Laron_syndrome
acromegaly
gptkbp:binds gptkb:IGF-1_receptor
IGF binding proteins (IGFBPs)
insulin receptor (with lower affinity)
gptkbp:discoveredIn 1957
gptkbp:encodedBy gptkb:IGF1_gene
gptkbp:foundIn humans
other mammals
gptkbp:function regulates cell growth and development
stimulates systemic body growth
gptkbp:halfLife 12-15 hours (bound to binding proteins)
https://www.w3.org/2000/01/rdf-schema#label insulin-like growth factor I protein
gptkbp:locatedOnChromosome chromosome 12q23.2
gptkbp:medicalUse diagnosis of growth disorders
treatment of growth failure
gptkbp:molecularWeight 7.6 kDa
gptkbp:orthologIn gptkb:insulin-like_growth_factor_II_protein
gptkbp:presentIn blood plasma
gptkbp:producedBy liver
gptkbp:regulates recombinant human growth hormone
gptkbp:relatedTo gptkb:insulin
gptkbp:role fetal development
bone growth
muscle growth
gptkbp:sequence 70 amino acids
gptkbp:structure single-chain polypeptide
gptkbp:UniProtID P05019
gptkbp:bfsParent gptkb:insulin-like_growth_factor_II_protein
gptkbp:bfsLayer 7