indoleamine 2,3-dioxygenase 1

URI: https://gptkb.org/entity/indoleamine_2,3-dioxygenase_1
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy gptkb:interferon-gamma
gptkbp:alternativeName gptkb:INDO
gptkb:IDO
gptkb:indoleamine-pyrrole_2,3-dioxygenase
gptkbp:associatedWith chronic inflammation
cancer immune evasion
gptkbp:biologicalProcess oxidoreductase activity
gptkbp:catalyzes oxidation of tryptophan to N-formylkynurenine
gptkbp:cofactor hemoglobin
gptkbp:EC_number 1.13.11.52
gptkbp:encodedBy gptkb:IDO1_gene
gptkbp:expressedIn gptkb:placenta
dendritic cells
macrophages
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:gene gptkb:IDO1
gptkbp:GO_term GO:0004517
https://www.w3.org/2000/01/rdf-schema#label indoleamine 2,3-dioxygenase 1
gptkbp:inhibitedBy 1-methyl-tryptophan
gptkbp:involves immune regulation
tryptophan catabolism
gptkbp:locatedIn gptkb:cytoplasm
gptkbp:locatedOnChromosome gptkb:8p11.21
gptkbp:OMIM 147780
gptkbp:PDB gptkb:2D0T
gptkbp:product N-formylkynurenine
gptkbp:regulates T cell proliferation
immune tolerance
gptkbp:substrate L-tryptophan
gptkbp:UniProtID P14902
gptkbp:bfsParent gptkb:IDO1_gene
gptkb:epacadostat
gptkbp:bfsLayer 8