indoleamine 2,3-dioxygenase 1

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:activatedBy	gptkb:interferon-gamma
gptkbp:alternativeName	gptkb:INDO gptkb:IDO gptkb:indoleamine-pyrrole_2,3-dioxygenase
gptkbp:associatedWith	chronic inflammation cancer immune evasion
gptkbp:biologicalProcess	oxidoreductase activity
gptkbp:catalyzes	oxidation of tryptophan to N-formylkynurenine
gptkbp:cofactor	gptkb:hemoglobin
gptkbp:EC_number	1.13.11.52
gptkbp:encodedBy	gptkb:IDO1_gene
gptkbp:expressedIn	gptkb:placenta dendritic cells macrophages
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:gene	gptkb:IDO1
gptkbp:GO_term	GO:0004517
gptkbp:inhibitedBy	1-methyl-tryptophan
gptkbp:involves	immune regulation tryptophan catabolism
gptkbp:locatedIn	gptkb:cytoplasm
gptkbp:locatedOnChromosome	gptkb:8p11.21
gptkbp:OMIM	147780
gptkbp:PDB	gptkb:2D0T
gptkbp:product	N-formylkynurenine
gptkbp:regulates	T cell proliferation immune tolerance
gptkbp:substrate	L-tryptophan
gptkbp:UniProtID	P14902
gptkbp:bfsParent	gptkb:IDO1_gene gptkb:epacadostat
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	indoleamine 2,3-dioxygenase 1