dehydroepiandrosterone (DHEA)

URI: https://gptkb.org/entity/dehydroepiandrosterone_(DHEA)
GPTKB entity
Statements (61)
Predicate Object
gptkbp:instanceOf gptkb:hormone
gptkbp:ATCCode G03XX01
gptkbp:biosynthesized_from gptkb:pregnenolone
gptkbp:CASNumber 53-43-0
gptkbp:chemicalFormula C19H28O2
gptkbp:contraindication pregnancy
breastfeeding
hormone-sensitive cancers
gptkbp:convertedTo gptkb:androstenedione
gptkb:estradiol
estrone
testosterone
gptkbp:excreted_as DHEA sulfate (DHEAS)
gptkbp:firstIsolatedFrom 1934
gptkbp:foundIn adrenal glands
gptkbp:hasInChIKey FMGSKWYWMVUUJI-XGXHKTLJSA-N
gptkbp:hasUNII AE45V16LKN
gptkbp:heldBy gptkb:neurosteroid
gptkb:prohormone
C19 steroid
endogenous hormone
androgen precursor
controlled substance (Canada, Australia)
over-the-counter supplement (US)
unscheduled drug (US)
gptkbp:IUPACName 3β-hydroxyandrost-5-en-17-one
gptkbp:KEGGID C00585
gptkbp:levels_decline_with age
gptkbp:levels_peak_at age 20–30
gptkbp:meltingPoint 148–151 °C
gptkbp:metabolite_of cholesterol
gptkbp:molecularWeight 288.42 g/mol
gptkbp:predecessor testosterone
estrogens
gptkbp:producedBy brain
adrenal cortex
gonads
gptkbp:PubChem_CID 5670
5881
CHEMBL118
DB02789
gptkbp:regulates gptkb:pituitary_gland
gptkb:ACTH
gptkbp:sideEffect hair loss
acne
mood changes
gynecomastia
hirsutism
liver dysfunction (rare)
gptkbp:synonym 3β-hydroxyandrost-5-en-17-one
prasterone
androstenolone
gptkbp:usedFor gptkb:dietary_supplement
gptkb:depression
gptkb:bone
adrenal insufficiency
anti-aging
improving libido
gptkbp:bfsParent gptkb:androstenedione
gptkbp:bfsLayer 8
https://www.w3.org/2000/01/rdf-schema#label dehydroepiandrosterone (DHEA)