tissue factor pathway inhibitor

URI: https://gptkb.org/entity/tissue_factor_pathway_inhibitor
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:TFPI
gptkbp:alternativeSplicing gptkb:TFPI-alpha
gptkb:TFPI-beta
gptkbp:associatedWith hemophilia
venous thromboembolism
gptkbp:category gptkb:anticoagulant
gptkb:serine_protease
gptkbp:discoveredBy gptkb:Broze_et_al.
gptkbp:discoveredIn 1987
gptkbp:Entrez_Gene_ID ENSG00000003402
gptkbp:expressedIn gptkb:cancer
gptkb:placenta
liver
gptkbp:foundIn gptkb:plasma
platelets
endothelial cells
gptkbp:function inhibits tissue factor (TF)-induced coagulation
regulates blood coagulation
gptkbp:gene gptkb:TFPI_gene
gptkbp:HGNC_ID HGNC:11740
https://www.w3.org/2000/01/rdf-schema#label tissue factor pathway inhibitor
gptkbp:inhibitedBy gptkb:factor_Xa
gptkb:factor_VIIa/tissue_factor_complex
gptkbp:locatedOnChromosome gptkb:chromosome_2q32
gptkbp:molecularWeight ~34 kDa
gptkbp:OMIM 152440
gptkbp:pathway hemostasis
extrinsic pathway of coagulation
gptkbp:significance deficiency associated with thrombosis risk
gptkbp:structure contains three Kunitz-type domains
gptkbp:UniProtID P10646
gptkbp:bfsParent gptkb:Factor_X
gptkbp:bfsLayer 6