factor VIIIa

GPTKB entity

Statements (17)
Predicate Object
gptkbp:instanceOf gptkb:protein
enzyme cofactor
gptkbp:activatedBy factor X (in presence of factor IXa and Ca2+)
gptkbp:component tenase complex
gptkbp:deficiencyCauses gptkb:hemophilia_A
gptkbp:EC_number 3.4.21.5 (as part of tenase complex)
gptkbp:function cofactor for factor IXa
gptkbp:gene gptkb:F8
https://www.w3.org/2000/01/rdf-schema#label factor VIIIa
gptkbp:inhibitedBy activated protein C
gptkbp:is_activated_form_of factor VIII
gptkbp:location gptkb:plasma
gptkbp:role blood coagulation
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure heterotrimer of A1, A2, and A3-C1-C2 domains
gptkbp:bfsParent gptkb:factor_IX
gptkbp:bfsLayer 6