extracellular superoxide dismutase

URI: https://gptkb.org/entity/extracellular_superoxide_dismutase
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alsoKnownAs gptkb:SOD3
gptkb:EC-SOD
gptkbp:cofactor copper
zinc
gptkbp:discoveredBy Marklund and Marklund
gptkbp:discoveredIn 1982
gptkbp:EC_number 1.15.1.1
gptkbp:encodedBy SOD3 gene
gptkbp:family gptkb:superoxide_dismutase_family
gptkbp:foundIn humans
mammals
gptkbp:function catalyzes the dismutation of superoxide radicals
gptkbp:GO_term gptkb:GO:0004784
https://www.w3.org/2000/01/rdf-schema#label extracellular superoxide dismutase
gptkbp:involvedIn antioxidant defense
oxidative stress response
gptkbp:locatedOnChromosome gptkb:chromosome_4q31.3
gptkbp:location extracellular space
gptkbp:molecularWeight 135 kDa (tetramer)
gptkbp:OMIM 185490
gptkbp:presentIn gptkb:plasma
extracellular matrix
lung tissue
vascular tissue
gptkbp:product hydrogen peroxide (H2O2)
molecular oxygen (O2)
gptkbp:significance mutations associated with amyotrophic lateral sclerosis
implicated in cardiovascular diseases
gptkbp:structure homotetramer
gptkbp:substrate superoxide anion (O2−)
gptkbp:UniProtID P08294
gptkbp:bfsParent gptkb:extracellular_SOD
gptkbp:bfsLayer 7