Properties (56)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:healthcare_organization
|
| gptkbp:age |
50-60 years
|
| gptkbp:associated_with |
myeloproliferative neoplasms
hepatomegaly splenomegaly |
| gptkbp:causedBy |
gptkb:Philadelphia_chromosome
|
| gptkbp:clinicalTrials |
Dasatinib studies
Imatinib studies Nilotinib studies |
| gptkbp:demographics |
1-2 cases per 100,000 people
|
| gptkbp:diseaseResistance |
blood test
bone marrow biopsy depends on age and health status depends on phase at diagnosis depends on response to treatment |
| gptkbp:events |
September
|
| gptkbp:gender |
more common in males
|
| gptkbp:geneticDiversity |
BCR-ABL fusion gene
|
| gptkbp:goal |
remission
|
| https://www.w3.org/2000/01/rdf-schema#label |
CML
|
| gptkbp:impact |
hospitalization
injection oral medication Tyrosine kinase inhibitors chemotherapy stem cell transplant blood cells |
| gptkbp:introduced |
1973
|
| gptkbp:is_monitored_by |
PCR_testing
|
| gptkbp:lifespan |
70-90% with treatment
|
| gptkbp:notableContestants |
low platelet count
elevated white blood cell count presence of immature cells |
| gptkbp:number_of_stages |
accelerated phase
blast phase chronic phase |
| gptkbp:provides |
gptkb:Leukemia_&_Lymphoma_Society
gptkb:CML_Advocates_Network |
| gptkbp:relatedPatent |
anemia
infections thrombocytopenia blast crisis |
| gptkbp:research |
recommended
|
| gptkbp:research_focus |
targeted therapy
genetic therapies new drug development |
| gptkbp:riskManagement |
age
family history exposure to radiation |
| gptkbp:symptoms |
fatigue
weight loss fever night sweats bone pain easy bruising pallor |