|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:drug
|
|
gptkbp:ATCCode
|
L01XX05
|
|
gptkbp:blackBoxWarning
|
false
|
|
gptkbp:CASNumber
|
127-07-1
|
|
gptkbp:category
|
gptkb:WHO_essential_medicine
antineoplastic agent
orphan drug
|
|
gptkbp:contraindication
|
pregnancy
severe bone marrow depression
|
|
gptkbp:discoveredBy
|
gptkb:Hans_Krebs
|
|
gptkbp:discoveredIn
|
1869
|
|
gptkbp:eliminationHalfLife
|
3-4 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasMolecularFormula
|
CH4N2O2
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
hydroxyurea
|
|
gptkbp:IUPACName
|
gptkb:hydroxycarbamide
|
|
gptkbp:KEGGID
|
D00341
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
ribonucleotide reductase inhibitor
|
|
gptkbp:meltingPoint
|
132°C
|
|
gptkbp:MeSH_ID
|
D006821
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
3531
3657
CHEMBL467
DB01005
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
hair loss
bone marrow suppression
skin ulcer
|
|
gptkbp:synonym
|
gptkb:hydroxycarbamide
|
|
gptkbp:UNII
|
X6Q56QN7X0
|
|
gptkbp:usedFor
|
gptkb:chronic_myelogenous_leukemia
gptkb:sickle_cell_anemia
gptkb:polycythemia_vera
essential thrombocythemia
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:Osler-Vaquez_disease
|
|
gptkbp:bfsLayer
|
5
|