biologic DMARDs

GPTKB entity

Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:drug
disease-modifying antirheumatic drug
gptkbp:administeredBy injection
infusion
gptkbp:alternativeTo gptkb:conventional_synthetic_DMARDs
gptkbp:approvedBy gptkb:FDA
late 1990s
gptkbp:category monoclonal antibodies
recombinant proteins
fusion proteins
gptkbp:combines gptkb:methotrexate
gptkbp:compatibleWith osteoarthritis
gout
gptkbp:contraindication active infection
latent tuberculosis (untreated)
gptkbp:cost high
gptkbp:example gptkb:rituximab
gptkb:ustekinumab
gptkb:tocilizumab
gptkb:etanercept
gptkb:golimumab
gptkb:infliximab
gptkb:abatacept
gptkb:certolizumab_pegol
gptkb:adalimumab
gptkb:secukinumab
https://www.w3.org/2000/01/rdf-schema#label biologic DMARDs
gptkbp:mechanismOfAction target specific components of the immune system
gptkbp:monitors regular blood tests
screening for infections
gptkbp:routeOfAdministration subcutaneous
intravenous
gptkbp:sideEffect allergic reactions
injection site reactions
increased risk of infection
malignancy (rare)
gptkbp:storage refrigeration required
gptkbp:target gptkb:interleukin-6
gptkb:B_cells
gptkb:T_cells
gptkb:tumor_necrosis_factor_alpha
gptkbp:usedFor gptkb:juvenile_idiopathic_arthritis
gptkb:systemic_lupus_erythematosus
gptkb:psoriatic_arthritis
rheumatoid arthritis
ankylosing spondylitis
gptkbp:bfsParent gptkb:DMARDs
gptkbp:bfsLayer 7