Statements (55)
Predicate | Object |
---|---|
gptkbp:instance_of |
gptkb:monoclonal_antibody
|
gptkbp:administered_by |
subcutaneous injection
|
gptkbp:approves |
gptkb:2009
gptkb:FDA |
gptkbp:biologic_class |
Ig G1 kappa monoclonal antibody
|
gptkbp:chemical_formula |
C_45 H_69 N_13 O_13 S
|
gptkbp:clinical_trial |
Phase 3
|
gptkbp:clinical_use |
chronic inflammatory conditions
|
gptkbp:contraindication |
active infections
hypersensitivity to the drug |
gptkbp:developed_by |
gptkb:Janssen_Pharmaceuticals
|
gptkbp:drug_interactions |
immunosuppressants
live vaccines |
gptkbp:excretion |
primarily through the reticuloendothelial system
|
gptkbp:financial_stability |
stable for 24 hours at room temperature after reconstitution
|
gptkbp:formulation |
lyophilized powder for injection
|
https://www.w3.org/2000/01/rdf-schema#label |
ustekinumab
|
gptkbp:indication |
gptkb:ankylosing_spondylitis
gptkb:psoriatic_arthritis |
gptkbp:invention |
2028
|
gptkbp:is_monitored_by |
monitor for allergic reactions
monitor for signs of infection |
gptkbp:lifespan |
15 to 46 days
|
gptkbp:marketed_as |
gptkb:Stelara
|
gptkbp:mechanism_of_action |
inhibits IL-12 and IL-23
|
gptkbp:patient_education |
advise on potential side effects
importance of follow-up appointments instruct on proper injection technique |
gptkbp:provides_guidance_on |
recommended for moderate to severe cases
|
gptkbp:recommissioned |
requires sterile water for injection
|
gptkbp:research_areas |
gptkb:disease
autoimmune diseases rheumatology dermatology |
gptkbp:route_of_administration |
subcutaneous
|
gptkbp:service_frequency |
every 12 weeks after initial dose
|
gptkbp:side_effect |
fatigue
headache nausea rash increased risk of infections injection site reactions thrombocytopenia hypersensitivity reactions elevated liver enzymes |
gptkbp:storage |
refrigerated
|
gptkbp:targets |
gptkb:interleukin-23
interleukin-12 |
gptkbp:used_for |
treatment of psoriasis
treatment of ulcerative colitis treatment of Crohn's disease |
gptkbp:website |
abdomen or thigh
|
gptkbp:weight |
150 k Da
|
gptkbp:bfsParent |
gptkb:Stelara
|
gptkbp:bfsLayer |
5
|