|
gptkbp:instanceOf
|
gptkb:protein
gptkb:neurotrophin
|
|
gptkbp:alternativeName
|
gptkb:NGF
|
|
gptkbp:associatedWith
|
gptkb:peripheral_neuropathy
gptkb:Alzheimer's_disease
neurodegenerative diseases
|
|
gptkbp:category
|
gptkb:growth_factor
gptkb:signaling_molecule
extracellular protein
|
|
gptkbp:discoveredBy
|
gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
|
|
gptkbp:discoveredIn
|
1950s
|
|
gptkbp:function
|
promotes survival and differentiation of neurons
regulates growth, maintenance, and survival of nerve cells
nerve growth factor receptor binding
|
|
gptkbp:gene
|
NGF gene
|
|
gptkbp:GOProcess
|
cell survival
axon guidance
neuron differentiation
|
|
gptkbp:locatedOnChromosome
|
1p13.1 (human)
|
|
gptkbp:medicalUse
|
investigated for neurodegenerative disease therapy
|
|
gptkbp:molecularWeight
|
~26 kDa (dimer)
|
|
gptkbp:NobelPrizeYear
|
Rita Levi-Montalcini and Stanley Cohen (1986, Physiology or Medicine)
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
gptkb:right
|
|
gptkbp:orthologIn
|
gptkb:mouse_NGF
gptkb:rat_NGF
|
|
gptkbp:PDB
|
gptkb:1BET
|
|
gptkbp:predecessor
|
proNGF
|
|
gptkbp:recipient
|
gptkb:TrkA
gptkb:p75NTR
|
|
gptkbp:sequence
|
118 amino acids (mature form)
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:tissue_specificity
|
gptkb:thyroid
gptkb:cancer
gptkb:skin
gptkb:skeletal_muscle
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:testis
gptkb:thymus
gptkb:lymph_node
heart
central nervous system
liver
spleen
bladder
bone marrow
pancreas
peripheral nervous system
stomach
uterus
intestine
immune cells
salivary glands
|
|
gptkbp:UniProtID
|
gptkb:P01138
|
|
gptkbp:bfsParent
|
gptkb:beta-NGF
gptkb:beta-NGF_protein
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
beta-Nerve Growth Factor
|