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gptkbp:instanceOf
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gptkb:protein
neurotrophin
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gptkbp:alternativeName
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gptkb:NGF
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gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
neurodegenerative diseases
peripheral neuropathy
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gptkbp:category
|
growth factor
signaling molecule
extracellular protein
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gptkbp:discoveredBy
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gptkb:Rita_Levi-Montalcini
gptkb:Stanley_Cohen
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gptkbp:discoveredIn
|
1950s
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gptkbp:function
|
promotes survival and differentiation of neurons
regulates growth, maintenance, and survival of nerve cells
nerve growth factor receptor binding
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gptkbp:gene
|
NGF gene
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gptkbp:GOProcess
|
cell survival
axon guidance
neuron differentiation
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https://www.w3.org/2000/01/rdf-schema#label
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beta-Nerve Growth Factor
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gptkbp:locatedOnChromosome
|
1p13.1 (human)
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gptkbp:medicalUse
|
investigated for neurodegenerative disease therapy
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gptkbp:molecularWeight
|
~26 kDa (dimer)
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gptkbp:NobelPrizeYear
|
Rita Levi-Montalcini and Stanley Cohen (1986, Physiology or Medicine)
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gptkbp:organism
|
gptkb:human
gptkb:mouse
right
|
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gptkbp:orthologIn
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gptkb:mouse_NGF
gptkb:rat_NGF
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gptkbp:PDB
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gptkb:1BET
|
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gptkbp:predecessor
|
proNGF
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gptkbp:recipient
|
gptkb:TrkA
gptkb:p75NTR
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gptkbp:sequence
|
118 amino acids (mature form)
|
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gptkbp:structure
|
homodimer
|
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gptkbp:tissue_specificity
|
gptkb:thyroid
gptkb:cancer
gptkb:skin
gptkb:skeletal_muscle
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:testis
gptkb:thymus
heart
central nervous system
liver
spleen
bladder
bone marrow
lymph node
pancreas
peripheral nervous system
stomach
uterus
intestine
immune cells
salivary glands
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gptkbp:UniProtID
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gptkb:P01138
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gptkbp:bfsParent
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gptkb:beta-NGF
gptkb:beta-NGF_protein
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gptkbp:bfsLayer
|
8
|