amine oxidase (flavin-containing) A

URI: https://gptkb.org/entity/amine_oxidase_(flavin-containing)_A
GPTKB entity
Statements (44)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alsoKnownAs gptkb:MAO-A
gptkbp:associatedWith gptkb:depression
anxiety
mood disorders
gptkbp:catalyzes oxidative deamination of amines
gptkbp:cofactor gptkb:FAD
gptkbp:discoveredBy gptkb:Mary_Bernheim
gptkbp:discoveredIn 1928
gptkbp:EC_number 1.4.3.4
gptkbp:expressedIn gptkb:cancer
gptkb:placenta
gptkb:small_intestine
brain
liver
gptkbp:family flavin-containing amine oxidase family
gptkbp:foundIn gptkb:human
other mammals
gptkbp:function degrades neurotransmitters such as serotonin, norepinephrine, and dopamine
gptkbp:gene gptkb:MAOA
https://www.w3.org/2000/01/rdf-schema#label amine oxidase (flavin-containing) A
gptkbp:inhibitedBy gptkb:clorgyline
gptkb:moclobemide
gptkbp:inhibitorType reversible
irreversible
gptkbp:locatedOnChromosome Xp11.3
gptkbp:location outer mitochondrial membrane
gptkbp:medicalUse antidepressant target
anxiolytic target
gptkbp:OMIM 309850
gptkbp:orthologIn gptkb:amine_oxidase_(flavin-containing)_B
gptkbp:product hydrogen peroxide
ammonia
aldehyde
gptkbp:proteinFamily PF01593
gptkbp:structure flavin-containing
gptkbp:substrate gptkb:tyramine
dopamine
norepinephrine
serotonin
tryptamine
gptkbp:UniProtID gptkb:P21397
gptkbp:bfsParent gptkb:monoamine_oxidase_A
gptkbp:bfsLayer 7