Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:gene |
| gptkbp:alternativeName |
gptkb:Topoisomerase_IIβ-binding_protein_1
|
| gptkbp:domain |
gptkb:BRCT_domain
|
| gptkbp:encodedBy |
gptkb:TOPBP1_gene
|
| gptkbp:Entrez_Gene_ID |
9531
ENSG00000119383 |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:fullName |
gptkb:DNA_topoisomerase_II-binding_protein_1
|
| gptkbp:function |
DNA replication
DNA damage response cell cycle checkpoint control |
| https://www.w3.org/2000/01/rdf-schema#label |
TopBP1
|
| gptkbp:interactsWith |
gptkb:ATR
gptkb:BRCA1 gptkb:E2F1 |
| gptkbp:involvedIn |
gptkb:G1/S_checkpoint
DNA replication initiation G2/M checkpoint activation of ATR kinase |
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:locatedOnChromosome |
3q22.1
|
| gptkbp:molecularWeight |
180 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:cancer
|
| gptkbp:OMIM |
605293
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
gptkb:Danio_rerio
gptkb:Mus_musculus |
| gptkbp:PDB |
5OQZ
|
| gptkbp:phosphorylates |
regulates activity
|
| gptkbp:UniProtID |
Q92547
|
| gptkbp:bfsParent |
gptkb:FANCJ
|
| gptkbp:bfsLayer |
6
|