Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:cancer
genomic stability |
| gptkbp:discoveredBy |
Yamane et al.
|
| gptkbp:encodes |
DNA topoisomerase 2-binding protein 1
|
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000119318
9575 |
| gptkbp:expressedIn |
various tissues
|
| gptkbp:function |
DNA replication
DNA damage response cell cycle checkpoint control |
| https://www.w3.org/2000/01/rdf-schema#label |
TOPBP1 gene
|
| gptkbp:interactsWith |
gptkb:ATR
gptkb:BRCA1 gptkb:MCM_complex DNA polymerase epsilon |
| gptkbp:locatedOnChromosome |
gptkb:chromosome_3
3q22.1 |
| gptkbp:mutationAssociatedWith |
genomic instability
|
| gptkbp:OMIM |
604990
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Topbp1
|
| gptkbp:proteinDomains |
BRCT domains
|
| gptkbp:UniProtID |
Q92547
|
| gptkbp:bfsParent |
gptkb:TopBP1
|
| gptkbp:bfsLayer |
7
|