Toll-like receptor 4 (TLR4)

URI: https://gptkb.org/entity/Toll-like_receptor_4_(TLR4)
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
pattern recognition receptor
gptkbp:activatedBy gptkb:MAPK_pathway
gptkb:NF-κB_pathway
gptkbp:alternativeName gptkb:CD284
Toll/interleukin-1 receptor-like protein 4
hToll
gptkbp:associatedWith asthma
atherosclerosis
sepsis
inflammatory bowel disease
gptkbp:discoveredBy gptkb:Bruce_Beutler
gptkbp:discoveredIn 1998
gptkbp:encodedBy gptkb:TLR4_gene
gptkbp:Entrez_Gene_ID ENSG00000136869
gptkbp:expressedIn dendritic cells
macrophages
endothelial cells
gptkbp:formsComplexWith gptkb:CD14
gptkb:MD-2
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function activation of innate immune response
recognition of lipopolysaccharide (LPS)
gptkbp:gene gptkb:TLR4
gptkbp:GO_term GO:0002224 (toll-like receptor signaling pathway)
GO:0008329 (signaling receptor activity)
gptkbp:homolog_in_mouse Tlr4
https://www.w3.org/2000/01/rdf-schema#label Toll-like receptor 4 (TLR4)
gptkbp:interactsWith gptkb:TRAM
MyD88
TRIF
TIRAP
gptkbp:involves inflammatory response
cytokine production
host defense against Gram-negative bacteria
gptkbp:ligand gptkb:taxol
heat shock proteins
lipopolysaccharide
gptkbp:locatedIn gptkb:cell_membrane
gptkbp:locatedOnChromosome chromosome 9q32-q33 (human)
gptkbp:molecularWeight 96 kDa
gptkbp:number_of_amino_acids 839
gptkbp:OMIM 603030
gptkbp:PDB 3FXI
gptkbp:postTranslationalModification phosphorylation
glycosylation
gptkbp:RefSeq NM_138554
gptkbp:UniProtID O00206
gptkbp:bfsParent gptkb:endotoxin
gptkbp:bfsLayer 5