Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
Tripartite motif-containing protein family
|
| gptkbp:C-terminalDomainVariants |
PRY/SPRY domain
ARF domain B30.2 domain COS domain EXO domain FN3 domain MATH domain NHL domain PHD-BROMO domain PLD domain |
| gptkbp:characterizedBy |
tripartite motif
|
| gptkbp:conservedIn |
invertebrates
vertebrates |
| gptkbp:domain |
RING finger domain
B-box domain coiled-coil region |
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
apoptosis
cell proliferation antiviral defense E3 ubiquitin ligase activity regulation of innate immunity |
| https://www.w3.org/2000/01/rdf-schema#label |
TRIM protein family
|
| gptkbp:includes |
gptkb:TRIM21
gptkb:TRIM37 gptkb:TRIM28 gptkb:TRIM19 gptkb:TRIM25 TRIM29 TRIM32 TRIM5 TRIM63 |
| gptkbp:involves |
gptkb:cancer
neurodegenerative diseases autoimmune diseases viral infections |
| gptkbp:memberOf |
RING-type E3 ubiquitin ligases
|
| gptkbp:numberOfMembersInHuman |
over 70
|
| gptkbp:proteinFamily |
TRIM genes
|
| gptkbp:regulates |
gptkb:NF-κB_pathway
cell cycle interferon signaling autophagy p53 pathway |
| gptkbp:structure |
N-terminal RING domain
coiled-coil region one or two B-box domains variable C-terminal domain |
| gptkbp:bfsParent |
gptkb:TRIM
|
| gptkbp:bfsLayer |
6
|