Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
gptkb:Ro52
gptkb:SS-A |
| gptkbp:associatedWith |
gptkb:systemic_lupus_erythematosus
gptkb:Sjögren's_syndrome autoimmune diseases |
| gptkbp:discoveredBy |
Tzioufas AG et al.
|
| gptkbp:discoveredIn |
1988
|
| gptkbp:domain |
RING finger domain
B-box domain coiled-coil domain PRY/SPRY domain |
| gptkbp:encodes |
TRIM21 protein
|
| gptkbp:Entrez_Gene_ID |
6737
|
| gptkbp:expressedIn |
various tissues
|
| gptkbp:function |
regulation of immune response
E3 ubiquitin ligase activity |
| gptkbp:HGNC_ID |
11312
|
| https://www.w3.org/2000/01/rdf-schema#label |
TRIM21 gene
|
| gptkbp:locatedOnChromosome |
gptkb:11p15.5
chromosome 11 |
| gptkbp:mutationAssociatedWith |
autoimmune disorders
|
| gptkbp:OMIM |
109092
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Trim21
|
| gptkbp:proteinFamily |
gptkb:TRIM_protein_family
|
| gptkbp:regulates |
innate immune signaling
antibody-dependent intracellular neutralization |
| gptkbp:UniProtID |
P19474
|
| gptkbp:bfsParent |
gptkb:TRIM21
|
| gptkbp:bfsLayer |
7
|