|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Triggering_receptor_expressed_on_myeloid_cells_2
CD365
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Nasu-Hakola_disease
frontotemporal dementia
|
|
gptkbp:discoveredIn
|
2000s
|
|
gptkbp:encodes
|
TREM2 protein
|
|
gptkbp:Entrez_Gene_ID
|
54209
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:bone
gptkb:microglia
brain
liver
spleen
macrophages
|
|
gptkbp:fullName
|
Triggering Receptor Expressed on Myeloid Cells 2
|
|
gptkbp:function
|
phagocytosis
regulation of immune response
microglial activation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
17761
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TREM2 gene
|
|
gptkbp:interactsWith
|
gptkb:DAP12
|
|
gptkbp:length
|
230 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
gptkb:chromosome_6
|
|
gptkbp:mutationAssociatedWith
|
increased risk of neurodegeneration
Q33X
R47H
T66M
Y38C
|
|
gptkbp:OMIM
|
605086
|
|
gptkbp:orthologInMouse
|
gptkb:Trem2
|
|
gptkbp:pathway
|
innate immune response
neuroinflammation
phagocytosis pathway
|
|
gptkbp:proteinFamily
|
gptkb:immunoglobulin_superfamily
transmembrane domain
cytoplasmic tail
immunoglobulin-like domain
|
|
gptkbp:regulates
|
inflammatory response
clearance of apoptotic neurons
lipid metabolism in brain
microglial proliferation
microglial response to injury
microglial survival
|
|
gptkbp:UniProtID
|
gptkb:Q9NZC2
|
|
gptkbp:bfsParent
|
gptkb:TREM2
|
|
gptkbp:bfsLayer
|
7
|