|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:Nasu-Hakola_disease
frontotemporal dementia
|
|
gptkbp:biologicalProcess
|
receptor activity
immune system process
cellular response to stimulus
|
|
gptkbp:cellularComponent
|
gptkb:cell_membrane
|
|
gptkbp:discoveredIn
|
2000s
|
|
gptkbp:encodes
|
TREM2 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000095970
54209
|
|
gptkbp:expressedIn
|
gptkb:microglia
macrophages
|
|
gptkbp:fullName
|
gptkb:Triggering_receptor_expressed_on_myeloid_cells_2
|
|
gptkbp:function
|
phagocytosis
regulation of immune response
modulation of inflammation
|
|
gptkbp:HGNC_ID
|
17761
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Trem2
|
|
gptkbp:interactsWith
|
gptkb:DAP12
|
|
gptkbp:locatedOnChromosome
|
6p21.1 (human)
|
|
gptkbp:mutationAssociatedWith
|
increased risk of neurodegeneration
|
|
gptkbp:OMIM
|
605086
|
|
gptkbp:orthologInMouse
|
Trem2 (mouse)
|
|
gptkbp:product
|
TREM2 protein
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
gptkb:Q9NZC2
|
|
gptkbp:bfsParent
|
gptkb:TREM2
|
|
gptkbp:bfsLayer
|
7
|