|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
sepsis
inflammation
immune response
rheumatoid arthritis
inflammatory bowel disease
|
|
gptkbp:cellSurfaceReceptor
|
yes
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:encodes
|
TREM1 protein
|
|
gptkbp:Entrez_Gene_ID
|
54210
ENSG00000124731
|
|
gptkbp:expressedIn
|
myeloid cells
|
|
gptkbp:fullName
|
triggering receptor expressed on myeloid cells 1
|
|
gptkbp:function
|
transmembrane signaling receptor activity
amplifies inflammatory responses
|
|
gptkbp:GOProcess
|
regulation of immune response
positive regulation of cytokine production
|
|
gptkbp:HGNC_ID
|
HGNC:17760
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TREM1 gene
|
|
gptkbp:inducedBy
|
gptkb:Bacteria
fungal infection
|
|
gptkbp:interactsWith
|
gptkb:DAP12
|
|
gptkbp:length
|
234 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.1
gptkb:chromosome_6
|
|
gptkbp:modulatedBy
|
neutrophil activation
monocyte activation
|
|
gptkbp:molecularWeight
|
26 kDa
|
|
gptkbp:mutationAssociatedWith
|
autoimmune disorders
increased susceptibility to infection
|
|
gptkbp:OMIM
|
605823
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Trem1
|
|
gptkbp:pathway
|
innate immune signaling
NF-kappaB activation
|
|
gptkbp:proteinFamily
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:regulates
|
inflammatory cytokine production
|
|
gptkbp:targetForTherapy
|
anti-inflammatory drugs
|
|
gptkbp:UniProtID
|
Q9NP99
|
|
gptkbp:bfsParent
|
gptkb:CD280
|
|
gptkbp:bfsLayer
|
8
|