|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:DR5
gptkb:CD262
gptkb:TNFRSF10B
KILLER
TRICK2
|
|
gptkbp:associatedWith
|
drug resistance
tumor progression
|
|
gptkbp:binds
|
gptkb:TRAIL
|
|
gptkbp:cellSurfaceMarker
|
true
|
|
gptkbp:disulfideBond
|
true
|
|
gptkbp:domain
|
death domain
|
|
gptkbp:encodedBy
|
gptkb:TNFRSF10B_gene
|
|
gptkbp:Entrez_Gene_ID
|
8795
ENSG00000089692
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:function
|
induces apoptosis
mediates cell death signaling
|
|
gptkbp:glycosylation
|
true
|
|
gptkbp:hasCytoplasmicDomain
|
true
|
|
gptkbp:hasExtracellularDomain
|
true
|
|
gptkbp:HGNC_ID
|
11907
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TRAIL-R2
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:caspase-8
TRAIL-R1
|
|
gptkbp:involvedIn
|
extrinsic apoptotic signaling pathway
|
|
gptkbp:length
|
440 amino acids
|
|
gptkbp:ligand
|
gptkb:TRAIL
|
|
gptkbp:locatedOnChromosome
|
chromosome 8
8p21.3
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:molecularWeight
|
47 kDa
|
|
gptkbp:OMIM
|
603639
|
|
gptkbp:orthologInMouse
|
Tnfrsf10b
|
|
gptkbp:overexpressedIn
|
some cancers
|
|
gptkbp:PDB
|
1D4V
1D0G
1DU3
3NKE
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
|
|
gptkbp:signalPeptide
|
true
|
|
gptkbp:significance
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:target
|
anticancer therapies
|
|
gptkbp:transmembraneDomains
|
true
|
|
gptkbp:UniProtID
|
gptkb:O14763
|
|
gptkbp:bfsParent
|
gptkb:CD262
gptkb:TNFRSF10B
gptkb:TNFRSF10B_gene
|
|
gptkbp:bfsLayer
|
8
|