|
gptkbp:instanceOf
|
gptkb:protein
pattern recognition receptor
|
|
gptkbp:activatedBy
|
gptkb:NF-κB_pathway
interferon regulatory factors
|
|
gptkbp:alternativeName
|
gptkb:CD283
gptkb:TLR3
|
|
gptkbp:associatedWith
|
autoimmune diseases
viral infections
|
|
gptkbp:discoveredIn
|
2001
|
|
gptkbp:encodedBy
|
gptkb:TLR3_gene
|
|
gptkbp:expressedIn
|
gptkb:microglia
dendritic cells
astrocytes
epithelial cells
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
initiates innate immune response
recognizes double-stranded RNA
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Toll-like receptor 3
|
|
gptkbp:involvedIn
|
antiviral response
|
|
gptkbp:ligand
|
double-stranded RNA
|
|
gptkbp:locatedIn
|
endosome membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4q35
|
|
gptkbp:modulatedBy
|
cytokine production
|
|
gptkbp:mutationAssociatedWith
|
gptkb:herpes_simplex_encephalitis
|
|
gptkbp:OMIM
|
603029
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:partOf
|
gptkb:Toll-like_receptor_family
innate immune system
|
|
gptkbp:PDB
|
2A0Z
|
|
gptkbp:regulates
|
type I interferon production
|
|
gptkbp:structure
|
transmembrane domain
leucine-rich repeat domain
Toll/interleukin-1 receptor (TIR) domain
|
|
gptkbp:UniProtID
|
O15455
|
|
gptkbp:bfsParent
|
gptkb:CD283
gptkb:TLR3
|
|
gptkbp:bfsLayer
|
8
|