|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:aggregatesFrom
|
pathological hallmark in ALS
pathological hallmark in FTD
|
|
gptkbp:alternativeName
|
gptkb:TARDBP
gptkb:TAR_DNA-binding_protein
|
|
gptkbp:associatedWith
|
amyotrophic lateral sclerosis
neurodegenerative diseases
frontotemporal dementia
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:domain
|
RNA recognition motif
glycine-rich domain
|
|
gptkbp:encodedBy
|
gptkb:TARDBP_gene
|
|
gptkbp:form
|
inclusions in neurons
|
|
gptkbp:fullName
|
gptkb:TAR_DNA-binding_protein_43
|
|
gptkbp:function
|
regulation of gene expression
RNA binding
splicing regulation
mRNA stability
|
|
gptkbp:hasBiomarker
|
ALS diagnosis
FTD diagnosis
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TDP-43
|
|
gptkbp:interactsWith
|
gptkb:RNA_polymerase_II
gptkb:FUS_protein
gptkb:SMN_complex
gptkb:hnRNP_proteins
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1p36.22
|
|
gptkbp:molecularWeight
|
43 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_ALS
gptkb:sporadic_ALS
|
|
gptkbp:pathology
|
cytoplasmic mislocalization
inclusion body formation
nuclear depletion
|
|
gptkbp:PDB
|
4BS2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
cleavage
ubiquitination
|
|
gptkbp:regulates
|
gptkb:CFTR_exon_9_splicing
apoptosis
neuronal development
|
|
gptkbp:reviewedBy
|
gptkb:Journal_of_Biological_Chemistry
gptkb:Nature_Reviews_Neuroscience
neurons
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
gptkb:Q13148
|
|
gptkbp:bfsParent
|
gptkb:TARDBP
|
|
gptkbp:bfsLayer
|
5
|