|
gptkbp:instance_of
|
gptkb:protein
|
|
gptkbp:bfsLayer
|
5
|
|
gptkbp:bfsParent
|
gptkb:Motor_Neurone_Disease
|
|
gptkbp:application
|
cellular stress response
|
|
gptkbp:associated_with
|
gptkb:Amyotrophic_lateral_sclerosis
|
|
gptkbp:clinical_trial
|
therapeutic targets
ALS treatments
biomarker for ALS
|
|
gptkbp:consequences
|
gptkb:physicist
|
|
gptkbp:data_type
|
neuronal cells
|
|
gptkbp:disease_resistance
|
RNA metabolism disruption
|
|
gptkbp:ecological_role
|
RNA processing
protein aggregation
|
|
gptkbp:established
|
small molecules
|
|
gptkbp:function
|
RNA splicing
RNA binding
|
|
gptkbp:genetic_diversity
|
highly conserved
loss of function
GWAS
SN Ps
familial ALS
linked to neurodegenerative diseases
|
|
gptkbp:has_member
|
part of ribonucleoprotein complexes
|
|
gptkbp:has_role
|
splicing regulation
|
|
gptkbp:has_website
|
RNA recognition motif
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TARDBP
|
|
gptkbp:intelligence
|
TDP-43
|
|
gptkbp:interacts_with
|
with RNA polymerase II
FUS protein
protein-RNA interaction
|
|
gptkbp:is_a_route_for
|
neuroinflammation
m RNA processing
|
|
gptkbp:is_involved_in
|
gene regulation
stress granule formation
|
|
gptkbp:is_represented_in
|
gptkb:microprocessor
ubiquitous
spinal cord
|
|
gptkbp:localization
|
cytoplasm
|
|
gptkbp:located_in
|
gptkb:physicist
|
|
gptkbp:modifications
|
phosphorylation
|
|
gptkbp:network
|
complex networks
|
|
gptkbp:nutritional_value
|
C-terminal domain
nuclear speckles
m RNA stability
TDP-43 family
dimeric form
|
|
gptkbp:organizes
|
inclusion bodies
|
|
gptkbp:partnership
|
hn RN Ps
|
|
gptkbp:promoter
|
gptkb:TARDBP
|
|
gptkbp:publishes
|
gptkb:academic_journal
|
|
gptkbp:regulatory_compliance
|
transcription factors
|
|
gptkbp:related_model
|
gptkb:video_game
|
|
gptkbp:research
|
gptkb:CRISPR-Cas9
nucleic acid binding
|
|
gptkbp:research_areas
|
gptkb:physicist
small molecule inhibitors
|
|
gptkbp:research_focus
|
neurobiology
|
|
gptkbp:role
|
transcription regulation
|
|
gptkbp:seed_dispersal
|
protein-coding gene
|
|
gptkbp:social_responsibility
|
gptkb:frontotemporal_dementia
neurodegeneration
SALS
|
|
gptkbp:subspecies
|
gptkb:chromosome_1
|
|
gptkbp:weight
|
43 k Da
|