TAR DNA-binding protein 43

URI: https://gptkb.org/entity/TAR_DNA-binding_protein_43
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:TDP-43
gptkbp:associatedWith amyotrophic lateral sclerosis
frontotemporal dementia
gptkbp:component gptkb:stress_granules
gptkbp:discoveredBy gptkb:Jean-Pierre_Julien
gptkbp:discoveredIn 1995
gptkbp:domain RNA recognition motif
glycine-rich domain
gptkbp:encodedBy gptkb:TARDBP_gene
gptkbp:form inclusions in neurodegenerative diseases
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulation of transcription
splicing regulation
RNA-binding
gptkbp:HGNC_ID 11574
https://www.w3.org/2000/01/rdf-schema#label TAR DNA-binding protein 43
gptkbp:locatedOnChromosome chromosome 1
gptkbp:molecularWeight 43 kDa
gptkbp:mutationAssociatedWith linked to ALS
linked to FTD
gptkbp:OMIM 605078
gptkbp:PDB 4IUF
gptkbp:postTranslationalModification phosphorylation
cleavage
ubiquitination
gptkbp:sequence 414 amino acids
gptkbp:subcellularLocation gptkb:nucleus
gptkb:cytoplasm
gptkbp:UniProtID gptkb:Q13148
gptkbp:bfsParent gptkb:TARDBP
gptkbp:bfsLayer 5