TAR DNA-binding protein 43

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:TDP-43
gptkbp:associatedWith	amyotrophic lateral sclerosis frontotemporal dementia
gptkbp:component	gptkb:stress_granules
gptkbp:discoveredBy	gptkb:Jean-Pierre_Julien
gptkbp:discoveredIn	1995
gptkbp:domain	RNA recognition motif glycine-rich domain
gptkbp:encodedBy	gptkb:TARDBP_gene
gptkbp:form	inclusions in neurodegenerative diseases
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	regulation of transcription splicing regulation RNA-binding
gptkbp:HGNC_ID	11574
gptkbp:locatedOnChromosome	chromosome 1
gptkbp:molecularWeight	43 kDa
gptkbp:mutationAssociatedWith	linked to ALS linked to FTD
gptkbp:OMIM	605078
gptkbp:PDB	4IUF
gptkbp:postTranslationalModification	phosphorylation cleavage ubiquitination
gptkbp:sequence	414 amino acids
gptkbp:subcellularLocation	gptkb:nucleus gptkb:cytoplasm
gptkbp:UniProtID	gptkb:Q13148
gptkbp:bfsParent	gptkb:TARDBP
gptkbp:bfsLayer	5
https://www.w3.org/2000/01/rdf-schema#label	TAR DNA-binding protein 43