|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:translocated_in_liposarcoma_protein
TLS
|
|
gptkbp:associatedWith
|
amyotrophic lateral sclerosis
frontotemporal dementia
|
|
gptkbp:component
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
Crozat et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:domain
|
zinc finger domain
RNA recognition motif
glycine-rich region
prion-like domain
|
|
gptkbp:encodedBy
|
gptkb:FUS_gene
|
|
gptkbp:Entrez_Gene_ID
|
2521
|
|
gptkbp:fullName
|
gptkb:Fused_in_Sarcoma_protein
|
|
gptkbp:function
|
DNA repair
RNA splicing
RNA binding
transcription regulation
DNA binding
DNA-binding
RNA-binding
|
|
gptkbp:GOProcess
|
transcription regulation
mRNA processing
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FUS protein
|
|
gptkbp:interactsWith
|
gptkb:RNA_polymerase_II
gptkb:TDP-43
gptkb:EWSR1
gptkb:SFPQ
gptkb:SMN1
gptkb:TAF15
gptkb:hnRNPA1
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p11.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~53 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:ALS6
nonsense
missense
protein aggregation
frameshift
cytoplasmic mislocalization
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:2LCW
|
|
gptkbp:postTranslationalModification
|
phosphorylation
methylation
|
|
gptkbp:UniProtID
|
gptkb:P35637
|
|
gptkbp:bfsParent
|
gptkb:FUS
|
|
gptkbp:bfsLayer
|
5
|