|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:antigenSpecificity
|
high
|
|
gptkbp:binds
|
gptkb:peptide-MHC_complex
|
|
gptkbp:composedOf
|
alpha chain
beta chain
delta chain
gamma chain
|
|
gptkbp:deficiencyCauses
|
immunodeficiency
|
|
gptkbp:discoveredBy
|
gptkb:James_P._Allison
|
|
gptkbp:encodedBy
|
TCR genes
|
|
gptkbp:expressedIn
|
gptkb:gamma-delta_T_cells
gptkb:CD4+_T_cells
gptkb:CD8+_T_cells
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:foundIn
|
gptkb:T_cells
|
|
gptkbp:function
|
antigen recognition
|
|
gptkbp:geneSegments
|
C segment
D segment
J segment
V segment
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
T-cell receptors
|
|
gptkbp:involvedIn
|
adaptive immune response
|
|
gptkbp:ligand
|
gptkb:MHC_molecule
antigen peptide
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:notExpressedOn
|
gptkb:NK_cells
gptkb:B_cells
dendritic cells
macrophages
|
|
gptkbp:relatedTo
|
B-cell receptor
|
|
gptkbp:requires
|
cell-mediated immunity
|
|
gptkbp:role
|
T cell activation
autoimmunity
cancer immunology
immune surveillance
pathogen recognition
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:studiedIn
|
immunology
|
|
gptkbp:target
|
gptkb:CAR-T_therapy
immunotherapy
|
|
gptkbp:type
|
gptkb:CD3_complex
gptkb:alpha-beta_TCR
gptkb:gamma-delta_TCR
|
|
gptkbp:variant
|
gptkb:V(D)J_recombination
|
|
gptkbp:bfsParent
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:bfsLayer
|
7
|