|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:approvedBy
|
gptkb:FDA
gptkb:EMA
1987
|
|
gptkbp:ATCCode
|
gptkb:C10AA
|
|
gptkbp:category
|
Lipid-lowering agents
Cardiovascular drugs
Enzyme inhibitors
|
|
gptkbp:chemicalFormula
|
Derived from fungal metabolites
|
|
gptkbp:contraindication
|
gptkb:Pregnancy
Active liver disease
|
|
gptkbp:discoveredBy
|
gptkb:Akira_Endo
|
|
gptkbp:drugInteraction
|
gptkb:Warfarin
Grapefruit juice
Fibrates
Macrolide antibiotics
|
|
gptkbp:effect
|
HDL cholesterol (slight increase)
LDL cholesterol (decreases)
Triglycerides (decreases)
|
|
gptkbp:eliminationHalfLife
|
Varies by drug
|
|
gptkbp:example
|
gptkb:Pitavastatin
gptkb:Atorvastatin
gptkb:Fluvastatin
gptkb:Lovastatin
gptkb:Pravastatin
gptkb:Rosuvastatin
gptkb:Simvastatin
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Statins
|
|
gptkbp:legalStatus
|
Many are generic
|
|
gptkbp:marketedAs
|
Multiple pharmaceutical companies
|
|
gptkbp:mechanismOfAction
|
Inhibit HMG-CoA reductase
|
|
gptkbp:metabolism
|
Liver
|
|
gptkbp:monitors
|
gptkb:Creatine_kinase
Liver function tests
|
|
gptkbp:origin
|
Natural and synthetic
|
|
gptkbp:pregnancyCategory
|
X (contraindicated)
|
|
gptkbp:prescriptionStatus
|
Prescription only
|
|
gptkbp:reduces
|
Stroke
Myocardial infarction
Cardiovascular mortality
|
|
gptkbp:routeOfAdministration
|
gptkb:Oral
|
|
gptkbp:sideEffect
|
Muscle pain
Memory loss
Peripheral neuropathy
Increased risk of diabetes
Liver enzyme elevation
Rhabdomyolysis
|
|
gptkbp:usedFor
|
Lowering cholesterol
Prevention of cardiovascular disease
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
Yes
|
|
gptkbp:bfsParent
|
gptkb:Cholesterol
gptkb:lovastatin
|
|
gptkbp:bfsLayer
|
6
|