|
gptkbp:instanceOf
|
gptkb:drug
statin
|
|
gptkbp:affiliatedWith
|
gptkb:World_Health_Organization's_List_of_Essential_Medicines
|
|
gptkbp:approvedBy
|
1996
|
|
gptkbp:ATCCode
|
gptkb:C10AA05
|
|
gptkbp:brand
|
gptkb:Lipitor
Sortis
Torvast
|
|
gptkbp:CASNumber
|
134523-00-5
|
|
gptkbp:chemicalFormula
|
C33H35FN2O5
|
|
gptkbp:contraindication
|
pregnancy
breastfeeding
active liver disease
|
|
gptkbp:developedBy
|
gptkb:Pfizer
|
|
gptkbp:discoveredIn
|
1985
|
|
gptkbp:eliminationHalfLife
|
14 hours
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:genericAvailable
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Atorvastatin
|
|
gptkbp:interactsWith
|
gptkb:milk
gptkb:cyclosporine
gptkb:clarithromycin
protease inhibitors
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:marketedAs
|
gptkb:United_States
|
|
gptkbp:mechanismOfAction
|
HMG-CoA reductase inhibitor
|
|
gptkbp:MedlinePlusID
|
a600045
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
558.64 g/mol
|
|
gptkbp:patentExpired
|
2011 (US)
|
|
gptkbp:pregnancyCategory
|
gptkb:X_(US)
|
|
gptkbp:proteinBinding
|
98%
|
|
gptkbp:PubChem_CID
|
60823
DB01076
|
|
gptkbp:riskFactor
|
gptkb:diabetes_mellitus
liver dysfunction
rhabdomyolysis
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
diarrhea
headache
muscle pain
liver enzyme abnormalities
|
|
gptkbp:UNII
|
83HN0GTJ6D
|
|
gptkbp:usedFor
|
lowering cholesterol
prevention of cardiovascular disease
|
|
gptkbp:bfsParent
|
gptkb:ANTIAS
gptkb:CHEMBL411
gptkb:C10AA
gptkb:Zentiva
gptkb:Statins
|
|
gptkbp:bfsLayer
|
7
|