Lovastatin

URI: https://gptkb.org/entity/Lovastatin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	statin cholesterol-lowering drug
gptkbp:approvalYear	1987
gptkbp:approvedBy	gptkb:FDA
gptkbp:ATCCode	C10AA02
gptkbp:bioavailability	less than 5%
gptkbp:brand	gptkb:Altocor gptkb:Mevacor
gptkbp:CASNumber	75330-75-5
gptkbp:category	lactone prodrug fungal metabolite lipid-lowering agent
gptkbp:chemicalFormula	C24H36O5
gptkbp:contraindication	gptkb:liver_disease pregnancy
gptkbp:discoveredBy	gptkb:Akira_Endo
gptkbp:drugInteraction	gptkb:milk gptkb:erythromycin itraconazole
gptkbp:eliminationHalfLife	2-5 hours
https://www.w3.org/2000/01/rdf-schema#label	Lovastatin
gptkbp:IUPACName	(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
gptkbp:KEGGID	D00348
gptkbp:legalStatus	prescription only
gptkbp:marketedAs	gptkb:United_States
gptkbp:mechanismOfAction	HMG-CoA reductase inhibitor
gptkbp:meltingPoint	174-178°C
gptkbp:metabolism	liver
gptkbp:molecularWeight	404.55 g/mol
gptkbp:origin	fermentation of Aspergillus terreus
gptkbp:patentExpired	2001
gptkbp:PubChem_CID	53232 DB00227 CHEMBL44632
gptkbp:routeOfAdministration	oral
gptkbp:sideEffect	muscle pain rhabdomyolysis liver enzyme elevation
gptkbp:UNII	BKJ8M8G8AP
gptkbp:usedFor	gptkb:familial_hypercholesterolemia prevention of cardiovascular disease
gptkbp:bfsParent	gptkb:C10AA gptkb:Statins
gptkbp:bfsLayer	7