|
gptkbp:instanceOf
|
gptkb:drug
statin
|
|
gptkbp:approvalYear
|
1994
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:C10AA04
|
|
gptkbp:bioavailability
|
24%
|
|
gptkbp:CASNumber
|
93957-55-2
|
|
gptkbp:contraindication
|
pregnancy
breastfeeding
active liver disease
|
|
gptkbp:developedBy
|
gptkb:Novartis
|
|
gptkbp:drugClass
|
statin
|
|
gptkbp:eliminationHalfLife
|
1-3 hours
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:form
|
capsule
extended-release tablet
|
|
gptkbp:hasMolecularFormula
|
C24H26FNO4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Fluvastatin
|
|
gptkbp:KEGGID
|
gptkb:D00351
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
HMG-CoA reductase inhibitor
|
|
gptkbp:MedlinePlusID
|
a696015
|
|
gptkbp:metabolism
|
liver (CYP2C9)
|
|
gptkbp:patentExpired
|
yes
|
|
gptkbp:pregnancyCategory
|
gptkb:X_(US)
gptkb:D_(Australia)
|
|
gptkbp:proteinBinding
|
98%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL1431
1548974
DB01095
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
headache
muscle pain
liver enzyme abnormalities
|
|
gptkbp:synonym
|
gptkb:Lescol
gptkb:Lescol_XL
|
|
gptkbp:UNII
|
4LX7YNV9T8
|
|
gptkbp:usedFor
|
gptkb:familial_hypercholesterolemia
prevention of cardiovascular disease
|
|
gptkbp:bfsParent
|
gptkb:C10AA
gptkb:Statins
|
|
gptkbp:bfsLayer
|
7
|