|
gptkbp:instanceOf
|
gptkb:drug
statin
|
|
gptkbp:approvalYear
|
1991
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:C10AA03
|
|
gptkbp:bioavailability
|
17%
|
|
gptkbp:brand
|
Pravachol
Lipostat
Selektine
|
|
gptkbp:CASNumber
|
81131-70-6
|
|
gptkbp:category
|
cardiovascular drug
cholesterol-lowering drug
|
|
gptkbp:chemicalFormula
|
C23H36O7
|
|
gptkbp:contraindication
|
gptkb:liver_disease
pregnancy
|
|
gptkbp:discoveredBy
|
gptkb:Sankyo
|
|
gptkbp:drugClass
|
lipid-lowering agent
|
|
gptkbp:eliminationHalfLife
|
1.8 hours
|
|
gptkbp:excretion
|
urine
bile
|
|
gptkbp:firstSynthesized
|
1980s
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Pravastatin
|
|
gptkbp:interactsWith
|
gptkb:cyclosporine
gptkb:gemfibrozil
gptkb:erythromycin
niacin
|
|
gptkbp:legalStatus
|
prescription only
off-patent
|
|
gptkbp:mechanismOfAction
|
HMG-CoA reductase inhibitor
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
424.52 g/mol
|
|
gptkbp:pregnancyCategory
|
gptkb:X_(US)
|
|
gptkbp:producedBy
|
fermentation of Nocardia autotrophica
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
headache
muscle pain
liver enzyme elevation
|
|
gptkbp:usedFor
|
gptkb:familial_hypercholesterolemia
prevention of cardiovascular disease
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:C10AA
gptkb:Statins
|
|
gptkbp:bfsLayer
|
7
|