|
gptkbp:instanceOf
|
gptkb:statin_medication
|
|
gptkbp:approvalYear
|
1991
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
C10AA01
|
|
gptkbp:bioavailability
|
less than 5%
|
|
gptkbp:brand
|
gptkb:Zocor
Simlup
Simvacor
|
|
gptkbp:CASNumber
|
79902-63-9
|
|
gptkbp:category
|
gptkb:enzyme
gptkb:cholesterol-lowering_drug
lipid-lowering agent
cardiovascular drug
|
|
gptkbp:chemicalFormula
|
C25H38O5
|
|
gptkbp:contraindication
|
pregnancy
active liver disease
|
|
gptkbp:discoveredBy
|
gptkb:Merck_&_Co.
|
|
gptkbp:discoveredIn
|
late 1980s
|
|
gptkbp:drugClass
|
gptkb:statin
|
|
gptkbp:eliminationHalfLife
|
2 hours
|
|
gptkbp:excretion
|
urine
feces
|
|
gptkbp:genericAvailable
|
yes
|
|
gptkbp:interactsWith
|
gptkb:milk
gptkb:cyclosporine
gptkb:warfarin
gptkb:erythromycin
azole antifungals
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
HMG-CoA reductase inhibitor
|
|
gptkbp:metabolism
|
gptkb:CYP3A4
|
|
gptkbp:molecularWeight
|
418.57 g/mol
|
|
gptkbp:origin
|
derived from lovastatin
|
|
gptkbp:patentExpired
|
2006
|
|
gptkbp:pregnancyCategory
|
gptkb:X_(US)
|
|
gptkbp:proteinBinding
|
95%
|
|
gptkbp:riskFactor
|
gptkb:muscular_dystrophy
rhabdomyolysis
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
muscle pain
digestive problems
liver enzyme abnormalities
|
|
gptkbp:synonym
|
MK-733
Simvastatina
Simvastatinum
|
|
gptkbp:usedFor
|
lowering cholesterol
reducing risk of cardiovascular disease
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
yes
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Simvastatin
|