Simvastatin

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf statin medication
gptkbp:approvalYear 1991
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode C10AA01
gptkbp:bioavailability less than 5%
gptkbp:brand gptkb:Zocor
Simlup
Simvacor
gptkbp:CASNumber 79902-63-9
gptkbp:category gptkb:enzyme
lipid-lowering agent
cardiovascular drug
cholesterol-lowering drug
gptkbp:chemicalFormula C25H38O5
gptkbp:contraindication pregnancy
active liver disease
gptkbp:discoveredBy gptkb:Merck_&_Co.
gptkbp:discoveredIn late 1980s
gptkbp:drugClass statin
gptkbp:eliminationHalfLife 2 hours
gptkbp:excretion urine
feces
gptkbp:genericAvailable yes
https://www.w3.org/2000/01/rdf-schema#label Simvastatin
gptkbp:interactsWith gptkb:milk
gptkb:cyclosporine
gptkb:warfarin
gptkb:erythromycin
azole antifungals
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction HMG-CoA reductase inhibitor
gptkbp:metabolism gptkb:CYP3A4
gptkbp:molecularWeight 418.57 g/mol
gptkbp:origin derived from lovastatin
gptkbp:patentExpired 2006
gptkbp:pregnancyCategory gptkb:X_(US)
gptkbp:proteinBinding 95%
gptkbp:riskFactor muscular dystrophy
rhabdomyolysis
gptkbp:routeOfAdministration oral
gptkbp:sideEffect muscle pain
digestive problems
liver enzyme abnormalities
gptkbp:synonym MK-733
Simvastatina
Simvastatinum
gptkbp:usedFor lowering cholesterol
reducing risk of cardiovascular disease
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:Merck_&_Co._(prior_to_spin-off)
gptkb:C10AA
gptkb:Zentiva
gptkb:Statins
gptkbp:bfsLayer 7