|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:GLI_transcription_factors
|
|
gptkbp:alias
|
gptkb:HHG-1
SHH-N
Sonic hedgehog protein
|
|
gptkbp:discoveredBy
|
gptkb:Matthew_P._Scott
gptkb:Clifford_Tabin
gptkb:Philip_Ingham
|
|
gptkbp:encodedBy
|
SHH gene
|
|
gptkbp:Entrez_Gene_ID
|
6469
|
|
gptkbp:expressedIn
|
notochord
floor plate
zone of polarizing activity
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cell signaling
morphogen
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Sonic hedgehog homolog
|
|
gptkbp:inhibitedBy
|
gptkb:sonidegib
gptkb:vismodegib
gptkb:cyclopamine
|
|
gptkbp:involvedIn
|
gptkb:cancer
cell proliferation
stem cell maintenance
tissue patterning
|
|
gptkbp:length
|
462 amino acids
|
|
gptkbp:locatedOnChromosome
|
7q36
|
|
gptkbp:memberOf
|
hedgehog signaling pathway
|
|
gptkbp:molecularWeight
|
45 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Gorlin_syndrome
gptkb:holoprosencephaly
basal cell carcinoma
|
|
gptkbp:OMIM
|
600725
|
|
gptkbp:orthologIn
|
Drosophila hedgehog gene
|
|
gptkbp:PDB
|
3M1N
|
|
gptkbp:postTranslationalModification
|
palmitoylation
cholesterol modification
|
|
gptkbp:recipient
|
gptkb:PTCH1
gptkb:PTCH2
|
|
gptkbp:relatedTo
|
gptkb:Indian_hedgehog
gptkb:Desert_hedgehog
|
|
gptkbp:role
|
embryonic development
organogenesis
neural tube development
limb patterning
|
|
gptkbp:symbol
|
gptkb:SHH
|
|
gptkbp:UniProtID
|
gptkb:Q15465
|
|
gptkbp:bfsParent
|
gptkb:SHH
|
|
gptkbp:bfsLayer
|
7
|