|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:OCT2
|
|
gptkbp:associatedWith
|
drug response variability
renal drug excretion
metformin transport
nephrotoxicity risk
type 2 diabetes treatment response
variation in drug pharmacokinetics
|
|
gptkbp:encodes
|
gptkb:Solute_carrier_family_22_member_2
|
|
gptkbp:Entrez_Gene_ID
|
6582
ENSG00000115902
|
|
gptkbp:expressedIn
|
gptkb:kidney
|
|
gptkbp:function
|
organic cation transporter
|
|
gptkbp:HGNC_ID
|
10966
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SLC22A2 gene
|
|
gptkbp:length
|
555 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:6q26
gptkb:chromosome_6
|
|
gptkbp:mutationAssociatedWith
|
metformin intolerance
|
|
gptkbp:OMIM
|
602608
|
|
gptkbp:orthologInMouse
|
gptkb:Slc22a2
|
|
gptkbp:proteinFamily
|
gptkb:solute_carrier_family
|
|
gptkbp:publicTransit
|
ABC transporter
|
|
gptkbp:regulates
|
inhibited by cimetidine
inhibited by quinidine
inhibited by trimethoprim
transcriptionally regulated by HNF4A
|
|
gptkbp:significance
|
drug-drug interactions
pharmacogenomics of metformin
renal clearance of drugs
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:transmembraneDomains
|
12
|
|
gptkbp:transportation
|
gptkb:metformin
gptkb:choline
gptkb:amiloride
gptkb:cisplatin
cimetidine
dopamine
serotonin
organic cations
creatinine
procainamide
|
|
gptkbp:UniProtID
|
O15244
|
|
gptkbp:bfsParent
|
gptkb:OCT2
|
|
gptkbp:bfsLayer
|
6
|