Solute carrier family 22 member 2

URI: https://gptkb.org/entity/Solute_carrier_family_22_member_2
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:OCT2
gptkb:SLC22A2
organic cation transporter 2
gptkbp:associatedWith pharmacogenomics
hypertension
chronic kidney disease
renal impairment
renal drug clearance
type 2 diabetes drug response
gptkbp:encodes gptkb:OCT2
gptkbp:Entrez_Gene_ID 6582
gptkbp:expressedIn gptkb:kidney
gptkbp:firstDescribed 1997
gptkbp:function organic cation transporter
gptkbp:gene gptkb:SLC22A2
gptkbp:geneType protein-coding
gptkbp:HGNC_ID 10966
https://www.w3.org/2000/01/rdf-schema#label Solute carrier family 22 member 2
gptkbp:inhibitedBy gptkb:verapamil
cimetidine
trimethoprim
quinidine
gptkbp:length over 30 kb
gptkbp:locatedOnChromosome gptkb:6q26
gptkbp:member gptkb:solute_carrier_family
gptkbp:mutationAssociatedWith renal tubular acidosis
altered drug response
metformin intolerance
gptkbp:numberOfExons 11
gptkbp:OMIM 602608
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Slc22a2
gptkbp:proteinFamily gptkb:major_facilitator_superfamily
gptkbp:significance pharmacokinetics
nephrotoxicity
drug-drug interactions
gptkbp:subcellularLocation gptkb:plasma_membrane
gptkbp:substrate gptkb:broadcaster
gptkbp:transmembraneDomains true
gptkbp:transportation gptkb:metformin
drugs
dopamine
serotonin
organic cations
creatinine
gptkbp:UniProtID O15244
gptkbp:bfsParent gptkb:OCT2
gptkb:SLC22A2
gptkbp:bfsLayer 6