|
gptkbp:instanceOf
|
gptkb:chemical_compound
gptkb:drug
|
|
gptkbp:ATCCode
|
C03DB01
|
|
gptkbp:bioavailability
|
15–25%
|
|
gptkbp:brand
|
Midamor
Moduretic (in combination with hydrochlorothiazide)
|
|
gptkbp:CASNumber
|
2016-88-8
|
|
gptkbp:chemicalFormula
|
C6H8ClN7O
|
|
gptkbp:color
|
yellow
|
|
gptkbp:contraindication
|
Addison's disease
severe renal impairment
hyperkalemia
|
|
gptkbp:developedBy
|
gptkb:Merck_&_Co.
|
|
gptkbp:discoveredBy
|
1967
|
|
gptkbp:eliminationHalfLife
|
6–9 hours
|
|
gptkbp:excretion
|
renal
|
|
gptkbp:form
|
gptkb:stone
|
|
gptkbp:found_in_combination_with
|
gptkb:hydrochlorothiazide
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
amiloride
|
|
gptkbp:KEGGID
|
gptkb:D07451
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
potassium-sparing diuretic
epithelial sodium channel blocker
|
|
gptkbp:meltingPoint
|
>300°C
|
|
gptkbp:MeSH_ID
|
D000662
|
|
gptkbp:molecularWeight
|
229.63 g/mol
|
|
gptkbp:pregnancyCategory
|
B
|
|
gptkbp:proteinBinding
|
~40%
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL653
2077
2162
DB00594
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
headache
hyperkalemia
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:synonym
|
N-amidino-3,5-diamino-6-chloropyrazinecarboxamide
|
|
gptkbp:UNII
|
7H264J967N
|
|
gptkbp:usedFor
|
treatment of hypertension
treatment of edema
treatment of congestive heart failure
|
|
gptkbp:bfsParent
|
gptkb:DEG/ENaC_family
gptkb:SLC22A2_gene
gptkb:ENaC
|
|
gptkbp:bfsLayer
|
7
|