|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
membrane_transporter
|
|
gptkbp:component
|
transmembrane domain
nucleotide-binding domain
|
|
gptkbp:database
|
gptkb:InterPro:_IPR003439
gptkb:Pfam:_PF00005
gptkb:UniProt:_P0A334
|
|
gptkbp:EC_number
|
3.6.3.-
|
|
gptkbp:example
|
gptkb:MRP1
gptkb:MDR1
gptkb:P-glycoprotein
gptkb:CFTR
gptkb:TAP_transporter
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
eukaryotes
|
|
gptkbp:fullName
|
ATP-binding cassette transporter
|
|
gptkbp:function
|
transmembrane transport
ATP hydrolysis
|
|
gptkbp:GO_term
|
GO:0042626
|
|
gptkbp:involvedIn
|
lipid transport
antigen processing
nutrient uptake
cellular detoxification
|
|
gptkbp:mechanismOfAction
|
uses ATP hydrolysis for transport
|
|
gptkbp:mutationAssociatedWith
|
drug resistance
cystic fibrosis
cholestasis
adrenoleukodystrophy
|
|
gptkbp:proteinFamily
|
gptkb:ABC_gene_family
|
|
gptkbp:relatedTo
|
antibiotic resistance
cystic fibrosis
multidrug resistance
|
|
gptkbp:structure
|
two transmembrane domains and two nucleotide-binding domains
|
|
gptkbp:subfamily
|
gptkb:ABCD
gptkb:ABCE
gptkb:ABCF
gptkb:ABCG
gptkb:ABCC
gptkb:ABCA
ABCB
|
|
gptkbp:transportation
|
drugs
ions
lipids
sugars
peptides
metabolites
|
|
gptkbp:bfsParent
|
gptkb:ABCC1
gptkb:translocase
gptkb:pfmdr1
|
|
gptkbp:bfsLayer
|
6
|