|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Solute_carrier_family_22_member_2
gptkb:hOCT2
|
|
gptkbp:associatedWith
|
drug transport
cisplatin nephrotoxicity
metformin uptake
|
|
gptkbp:encodedBy
|
gptkb:SLC22A2_gene
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
liver
|
|
gptkbp:fullName
|
gptkb:Organic_cation_transporter_2
|
|
gptkbp:function
|
transports organic cations across cell membranes
|
|
gptkbp:gene
|
gptkb:SLC22A2
|
|
gptkbp:hasPolymorphism
|
gptkb:rs316019
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
OCT2
|
|
gptkbp:inhibitedBy
|
gptkb:verapamil
cimetidine
quinidine
|
|
gptkbp:locatedOnChromosome
|
gptkb:6q26
|
|
gptkbp:location
|
basolateral membrane of renal proximal tubules
|
|
gptkbp:memberOf
|
gptkb:solute_carrier_family_22
|
|
gptkbp:molecularWeight
|
~61 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:publicTransit
|
polyspecific organic cation transporter
|
|
gptkbp:relatedTo
|
pharmacogenomics
renal drug clearance
|
|
gptkbp:significance
|
affects drug response and toxicity
|
|
gptkbp:structureType
|
transmembrane protein
|
|
gptkbp:substrate
|
gptkb:metformin
gptkb:cisplatin
dopamine
serotonin
creatinine
|
|
gptkbp:transmembraneDomains
|
12
|
|
gptkbp:UniProtID
|
O15244
|
|
gptkbp:bfsParent
|
gptkb:Transporter-2
|
|
gptkbp:bfsLayer
|
5
|