Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:alias |
gptkb:SIRT6
NAD-dependent protein deacetylase sirtuin-6 |
| gptkbp:associatedWith |
gptkb:cancer
gptkb:diabetes neurodegenerative diseases |
| gptkbp:cofactor |
NAD+
|
| gptkbp:encodedBy |
gptkb:SIRT6_gene
|
| gptkbp:foundIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:function |
histone deacetylase activity
ADP-ribosyltransferase activity |
| https://www.w3.org/2000/01/rdf-schema#label |
Sirtuin 6
|
| gptkbp:involvedIn |
aging
DNA repair genomic stability metabolic regulation inflammation regulation |
| gptkbp:locatedIn |
gptkb:nucleus
|
| gptkbp:locatedOnChromosome |
chromosome 19p13.3 (human)
|
| gptkbp:memberOf |
sirtuin family
|
| gptkbp:molecularWeight |
39 kDa
|
| gptkbp:orthologIn |
present in mammals
|
| gptkbp:product |
gptkb:SIRT6_gene
|
| gptkbp:regulates |
apoptosis
lipid metabolism cellular senescence mitochondrial function glucose metabolism base excision repair glycolysis oxidative stress response inflammatory response glucose homeostasis DNA double-strand break repair genomic stability telomere maintenance fatty acid metabolism NF-κB signaling DNA end resection HIF1α activity IGF signaling PARP1 activity histone H3K56 deacetylation histone H3K9 deacetylation telomeric chromatin |
| gptkbp:structure |
contains sirtuin domain
|
| gptkbp:UniProtID |
gptkb:Q8N6T7
|
| gptkbp:bfsParent |
gptkb:SIRT6
gptkb:4HJE |
| gptkbp:bfsLayer |
8
|