Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:associatedWith |
antibiotic resistance
|
| gptkbp:catalyzes |
hydrolysis of beta-lactam antibiotics
|
| gptkbp:discoveredIn |
1970s
|
| gptkbp:encodedBy |
chromosomal band
plasmid |
| gptkbp:enzymeCommissionNumber |
3.5.2.6
|
| gptkbp:family |
class A beta-lactamase
|
| gptkbp:foundIn |
gptkb:Bacteria
gptkb:Klebsiella_pneumoniae |
| gptkbp:gene |
blaSHV
|
| https://www.w3.org/2000/01/rdf-schema#label |
SHV beta-lactamase
|
| gptkbp:inhibitedBy |
gptkb:clavulanic_acid
gptkb:sulbactam tazobactam |
| gptkbp:mechanismOfAction |
hydrolytic cleavage of beta-lactam ring
|
| gptkbp:molecularWeight |
~29 kDa
|
| gptkbp:notableVariant |
gptkb:SHV-1
gptkb:SHV-2 gptkb:SHV-5 SHV-12 |
| gptkbp:resistantTo |
gptkb:cephalosporins
penicillins |
| gptkbp:structure |
serine active site
|
| gptkbp:substrate |
gptkb:ampicillin
gptkb:ceftazidime cefotaxime |
| gptkbp:bfsParent |
gptkb:Beta-lactamase
|
| gptkbp:bfsLayer |
7
|