Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
beta-lactamase
|
| gptkbp:discoveredIn |
1970s
|
| gptkbp:encodedBy |
gptkb:blaSHV-1_gene
|
| gptkbp:firstReported |
gptkb:Europe
|
| gptkbp:foundIn |
gptkb:Klebsiella_pneumoniae
|
| https://www.w3.org/2000/01/rdf-schema#label |
SHV-1
|
| gptkbp:inhibitedBy |
gptkb:clavulanic_acid
gptkb:sulbactam tazobactam |
| gptkbp:mechanismOfAction |
hydrolyzes beta-lactam ring
|
| gptkbp:molecularWeight |
~29 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:extended-spectrum_beta-lactamases_(ESBLs)
|
| gptkbp:prevalence |
gptkb:Enterobacteriaceae
|
| gptkbp:proteinFamily |
gptkb:SHV_beta-lactamases
|
| gptkbp:relatedTo |
gptkb:TEM-1
|
| gptkbp:resistantTo |
gptkb:cephalosporins
penicillins |
| gptkbp:sequence |
class A beta-lactamase
|
| gptkbp:significance |
antibiotic resistance
|
| gptkbp:substrateProfile |
broad-spectrum beta-lactams
|
| gptkbp:bfsParent |
gptkb:SHV
|
| gptkbp:bfsLayer |
7
|